Permutations And Combinations

Step 1: Understanding the problem.
We are asked to find the number of three-letter words that can be formed from the letters of the word 'VIRUS' without repetition. The word 'VIRUS' contains 5 distinct letters: V, I, R, U, and S.

Step 2: Calculating the number of arrangements.
The number of ways to choose 3 letters from 5 distinct letters is given by the number of permutations of 3 letters from 5. This is calculated as:

Step 3: Conclusion.
The correct answer is (C) 60, as there are 60 possible three-letter words that can be formed.