Parasites

Malaria is a disease caused by the Plasmodium parasite, transmitted to humans through the bite of infected Anopheles mosquitoes. During the lifecycle of the Plasmodium parasite, it invades red blood cells (RBCs) and multiplies within them. As the parasites grow, they eventually cause the RBCs to rupture.

The rupture of RBCs releases several substances, but the primary toxic substance is called Haemozoin. Haemozoin is a crystalline pigment formed by the Plasmodium parasite as it digests hemoglobin inside the RBCs. This substance is insoluble and accumulates in the tissues, contributing to the symptoms and pathology of malaria.

Therefore, the toxic substance released with the rupturing of RBCs during malaria is Haemozoin.