Gene Therapy

The genetic defect-Adenosine Deaminase (ADA) deficiency may be cured permanently by:

1.	periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
2.	administering adenosine deaminase activators
3.	introducing bone marrow cells producing ADA into cells at early embryonic stages
4.	invitro cell culture therapy

Which kind of therapy was given in 1990 to a four-year-old girl with Adenosine Deaminase (ADA) deficiency?

1. Gene therapy

2. Chemotherapy

3. Immunotherapy

4. Radiation therapy

Which of the following is commonly used as a vector for introducing a DNA fragment in human Lymphocytes?
1. Retrovirus
2. Ti plasmid
3. \lambda phage
4. pBR 322

When gene targeting involving gene amplification is attempted in an individual's tissue to treat disease, it is known as:

1.	Molecular diagnosis	2.	Safety testing
3.	Biopiracy	4.	Gene therapy

In gene therapy of Adenosine Deaminase (ADA) deficiency, the patient requires periodic infusion of genetically engineered lymphocytes because:

1.	Genetically engineered lymphocytes are not immortal cells.
2.	Retroviral vector is introduced into these lymphocytes.
3.	Gene isolated from marrow cells producing ADA is introduced into cells at embryonic stages
4.	Lymphocytes from patient's blood are grown in culture, outside the body.