Nitration of Phenol
When phenol reacts with concentrated nitric acid (HNO₃), it undergoes nitration primarily at the ortho and para positions relative to the hydroxyl group (-OH). The electron-donating effect of the hydroxyl group activates the aromatic ring for electrophilic substitution, making the ring more reactive towards nitration.
Reaction:
The nitration of phenol with concentrated nitric acid produces **2,4,6-Trinitrophenol (picric acid)**, which is a highly reactive compound. The reaction can be represented as:
Mechanism:
The hydroxyl group on phenol is an electron-donating group that activates the benzene ring, making it more susceptible to electrophilic attack. During nitration, the nitronium ion ( ) attacks the ortho and para positions of the phenol ring, resulting in the formation of **2,4,6-Trinitrophenol**, also known as **picric acid**.
Conclusion:
The nitration of phenol with nitric acid results in the formation of **2,4,6-Trinitrophenol (picric acid)**, which is a highly reactive compound due to the electron-donating effect of the hydroxyl group. The major product is formed at the ortho and para positions relative to the hydroxyl group.