CBSE-CLASS-XII SERIES
Biology

Human Reproduction

57 previous year questions.

Volume: 57 Ques
Yield: High

High-Yield Trend

5
2026
44
2025
8
2024

Chapter Questions
57 MCQs

01
PYQ 2024
medium
biology ID: cbse-cla
The periodic abstinence by a couple for family planning should be from:
1
Day 5 to 10 of menstrual cycle
2
Day 13 to 15 of menstrual cycle
3
Day 10 to 17 of menstrual cycle
4
Day 16 to 20 of menstrual cycle
02
PYQ 2024
medium
biology ID: cbse-cla
Which one of the following hormones is secreted by the human placenta that helps in the maintenance of pregnancy?
1
Relaxin
2
Human Chorionic Gonadotropin
3
Oxytocin
4
Human Placental Lactogen
03
PYQ 2024
medium
biology ID: cbse-cla
In humans, the secondary oocyte completes meiotic division when:
1
it gets implanted in the uterine endometrium.
2
it is released from the matured Graafian follicle.
3
it is penetrated by the sperm cell.
4
acrosomal enzymes break down the zona pellucida.
04
PYQ 2024
medium
biology ID: cbse-cla
Identify the growth curves ‘A’ and ‘B’.
05
PYQ 2024
medium
biology ID: cbse-cla
Sweden has an age distribution that is approximately of the same width near its base as at the apex. What does this indicate?
06
PYQ 2024
medium
biology ID: cbse-cla
Select the option that gives the correct identification of ovum, morula, and blastocyst in a human female reproduction system as shown in the following diagram:
1
Ovum – B, Morula – D, Blastocyst – F.
2
Ovum – A, Morula – B, Blastocyst – G.
3
Ovum – A, Morula – E, Blastocyst – G.
4
Ovum – B, Morula – D, Blastocyst – G.
07
PYQ 2024
medium
biology ID: cbse-cla
In a fertilized ovule of an angiosperm, the cells in which n, 2n, and 3n conditions respectively occur are:
1
antipodal, zygote, and endosperm
2
zygote, nucellus, and endosperm
3
endosperm, nucellus, and zygote
4
antipodals, synergids, and integuments
08
PYQ 2024
medium
biology ID: cbse-cla
Explain the processing of heterogeneous nuclear RNA (hnRNA) into a fully functional mRNA in eukaryotes. Where does this processing occur in the cell?
09
PYQ 2025
easy
biology ID: cbse-cla
Name any two VDs which might occur in a human female. State any two complications in a female if it is left untreated.
10
PYQ 2025
easy
biology ID: cbse-cla
Given below are few statements with reference to the uterus in the female reproductive system:
1
The myometrium exhibits strong contractions during the delivery of the baby.
2
The uterus opens into the cervix through a narrow opening called vagina.
3
The cavity of the cervix and the vagina forms the birth canal.
4
The outermost layer of uterus is a thin membranous perimetrium.
11
PYQ 2025
medium
biology ID: cbse-cla

Study the graphs given below for Case 1 and Case 2 showing different levels of certain hormones and answer the question that follows:

(a) Which hormone is responsible for the peak observed in Case 1 and Case 2? Write one function of that hormone.
(b) Write changes that take place in the ovary and uterus during follicular phase.
Student to attempt either sub-part (c) or (d):
(c) Name the hormone Q of Case 2. Write one function of hormone Q.
OR
(d) Which structure in the ovary will remain functional in Case 2? How is it formed?

12
PYQ 2025
medium
biology ID: cbse-cla
Shyam and Radha are expecting their first child with Radha being in her second month of pregnancy with no complications. Shyam’s family has a history of cystic fibrosis while Radha’s family has a history of Down’s syndrome, leading to a concern that the baby may have one of these conditions.
(a) Suggest and explain a way of testing if their baby is at risk for any genetic disorders.
(b) In case of presence of one or both of the abnormalities and posing a risk to the mother’s health, mention one possible option for them to consider. Is that option safe for Radha at the current gestational age? Justify.
(c) Under what conditions is the process mentioned in (b) illegal?
13
PYQ 2025
medium
biology ID: cbse-cla
Assertion (A): Saheli is the World’s first non-steroidal oral contraceptive pill.
Reason (R): It has been developed by National Institute of Immunology, New Delhi.
1
Both (A) and (R) are true and (R) is the correct explanation of (A).
2
Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3
(A) is true, but (R) is false.
4
(A) is false, but (R) is true.
14
PYQ 2025
medium
biology ID: cbse-cla

Match the following items of Column-I with that of Column-II:

1
(a)-(iv), (b)-(i), (c)-(ii), (d)-(iii)
2
(a)-(i), (b)-(ii), (c)-(iii), (d)-(iv)
3
(a)-(ii), (b)-(i), (c)-(iv), (d)-(iii)
4
(a)-(ii), (b)-(iv), (c)-(iii), (d)-(i)
15
PYQ 2025
medium
biology ID: cbse-cla

Given below are few statements with reference to the ovaries of the human female reproductive system:
(i) It is 2--4 cm in length and is connected to the pelvic wall by tendons.
(ii) It is covered by a thin epithelium which encloses the ovarian stroma.
(iii) The stroma is divided into a peripheral medulla and an inner cortex.
(iv) The ovaries are the primary female sex organs that produce the female gamete (ovum).
(v) Ovaries are located one on each side of the lower abdomen.
Choose the option with all the true statements from the given options:

1
(i), (ii) and (iv)
2
(ii), (iii) and (v)
3
(ii), (iv) and (v)
4
(i), (iii) and (iv)
16
PYQ 2025
medium
biology ID: cbse-cla

Student to attempt either option (A) or (B):
(A)
(i) Draw a diagrammatic sectional view of human seminiferous tubule (enlarged) and label the following:
(a) Cell that undergoes spermiogenesis
(b) Cell that nourish male gametes
(c) Cell which undergoes meiosis I and meiosis II.
(ii) State what is seminal plasma. Mention two constituents of seminal plasma. How is it different from semen?
OR
(B)
(i) Mention the event that induces the completion of the meiotic division of the secondary oocyte in humans.
(ii) Trace the journey of the zygote until its implantation inside the uterus.

17
PYQ 2025
medium
biology ID: cbse-cla
(a) Abbreviations used for the different modes of assisted reproductive technology are given below. Expand the abbreviations:
(i) ZIFT (ii) ICSI (iii) IUT (iv) GIFT
(b) Why is there a statutory ban on Amniocentesis? Give at least two reasons.
18
PYQ 2025
medium
biology ID: cbse-cla

Student to attempt either option (A) or (B):

(i) Identify ‘P’ and ‘Q’ labelled in the diagram.
(ii) Specify the source of the hormone ‘P’ and ‘Q’ marked in the diagram.
OR
(i) Identify ‘P’ and ‘Q’ labelled in the above diagram.
(ii) Write down the role of hormone ‘P’ in both males and females.

19
PYQ 2025
medium
biology ID: cbse-cla

(a) Name and explain the role of inner and middle walls of the human female uterus.
(b) Write the location and function of fimbriae in human female.

20
PYQ 2025
easy
biology ID: cbse-cla
Student to attempt either option (A) or (B):
(A)
(i) Explain why the milk produced by the mother during the initial days of lactation is considered to be very essential for the newborn infant.
(ii) What is the term used for the milk produced during the initial days of lactation?
OR
(B) Many children in the metro cities are suffering from a very common exaggerated response of the immune system to certain weak antigens in air.
(i) What is the term used for the above mentioned disease?
(ii) Name the main type of antibody produced by the immune system in response to this disease.
(iii) Which two main inflammation-causing chemicals are produced by the mast cells in such an immune response?
21
PYQ 2025
medium
biology ID: cbse-cla
Given below are a few statements with respect to spermatogenesis in a human male.
(i) Sperms are released from the seminiferous tubules by the process of spermiation.
(ii) Spermiogenesis involves the maturation of spermatids into sperms.
(iii) Spermatogonia produce spermatids by the process of spermiogenesis.
(iv) Meiosis II in secondary spermatocytes results in the formation of four equal haploid spermatids.
(v) Primary spermatocyte completes the first meiotic division forming two equal, diploid cells called secondary spermatocytes.
Choose the option with all true statements from the given options:
1
(i), (ii) and (iv)
2
(ii), (iii) and (v)
3
(ii), (iv) and (v)
4
(i), (ii) and (iv)
22
PYQ 2025
medium
biology ID: cbse-cla
Assertion (A): Corpus luteum secretes the hormone, progesterone.
Reason (R): Hormone Progesterone is essential for maintenance of the endometrium.
1
Both (A) and (R) are true and (R) is the correct explanation of (A).
2
Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3
(A) is true, but (R) is false.
4
(A) is false, but (R) is true.
23
PYQ 2025
medium
biology ID: cbse-cla
During the process of oogenesis in human female, the primary oocyte results in the formation of which of the following?
Choose the correct option.
1
Unequal cells — a smaller haploid secondary oocyte and a larger diploid polar body
2
Unequal cells — a larger haploid secondary oocyte and a smaller haploid polar body
3
Unequal cells — a smaller diploid secondary oocyte and a larger haploid polar body
4
Equal cells — a haploid secondary oocyte and a haploid polar body
24
PYQ 2025
easy
biology ID: cbse-cla
The number of autosomes present in a human secondary spermatocyte
25
PYQ 2025
medium
biology ID: cbse-cla
Explain the process of formation of placenta in a human female after the implantation of the blastocyst in the endometrium of the uterus.
26
PYQ 2025
easy
biology ID: cbse-cla
Student to attempt either option (A) or (B):
(A) Write two features of an ideal contraceptive. Explain any one natural contraceptive method that makes the chances of conception almost nil.
(B) Explain GIFT and ICSI.
27
PYQ 2025
medium
biology ID: cbse-cla

Given below are few statements with reference to oogenesis in a human female:

  • An unequal division of the primary oocyte forms a large secondary oocyte and a tiny first polar body.
  • A couple of thousands of oogonia are formed within each fetal ovary during embryonic development.
  • Primary oocytes start meiosis-I but it gets arrested temporarily at prophase-I during fetal development.
  • Fertilisation induces the completion of the meiotic division of the secondary oocyte.
  • A primary oocyte on meiosis forms an ovum and a polar body.

Choose the option with all true statements from the given options:

1
(i), (ii), (iv)
2
(ii), (iii), (v)
3
(ii), (iv), (v)
4
(i), (iii), (iv)
28
PYQ 2025
medium
biology ID: cbse-cla

Student to attempt either option (A) or (B):
(A) Explain what is meant by the term amniocentesis. How is this technique misused in India?
OR
(B) Name any two VDs which might occur in a human female. State any two complications in a female if it is left untreated.

29
PYQ 2025
medium
biology ID: cbse-cla
Assertion (A): Mode of action of pills and implants/injectables is similar.
Reason (R): The effective period of pills is much longer as compared to implants/injectables.
1
Both (A) and (R) are true and (R) is the correct explanation of (A).
2
Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3
(A) is true, but (R) is false.
4
(A) is false, but (R) is true.
30
PYQ 2025
medium
biology ID: cbse-cla
Given below are few statements with reference to the major events in the menstrual cycle of a human female:
  • During the follicular phase, the primary follicles grow to become a Graafian follicle.
  • Gonadotropins FSH and progesterone stimulate follicular development during the follicular phase.
  • LH surge induces rupture of Graafian follicle thereby releasing the corpus luteum.
  • Progesterone released by corpus luteum is essential for maintenance of endometrium.
  • Both LH and progesterone attain a peak level in the middle of the cycle.
Choose the option with all true statements from the given options:
1
(i), (ii) and (iv)
2
(ii), (iii) and (v)
3
(ii), (iv) and (v)
4
(i), (iii) and (iv)
31
PYQ 2025
medium
biology ID: cbse-cla
Penetration of the sperm in the ovum is followed by:
1
Formation of first polar body
2
Completion of Meiosis II
3
First Meiosis
4
Dissolution of zona pellucida
32
PYQ 2025
hard
biology ID: cbse-cla
Describe the changes in the ovary and the uterus as induced by the changes in the level of pituitary and ovarian hormones during menstrual cycle in a human female.
33
PYQ 2025
medium
biology ID: cbse-cla

Student to attempt either option (A) or (B):
(A) Write two features of an ideal contraceptive. Explain any one natural contraceptive method that makes the chances of conception almost nil.
OR
(B) Explain GIFT and ICSI.

34
PYQ 2025
medium
biology ID: cbse-cla
(A)

Distinguish between the two cells enclosed in a mature male gametophyte of an angiosperm.
Study the diagram given below showing the modes of pollination. Answer the questions that follow.
modes of pollination


The given diagram shows three methods of pollen transfer in plants. Examine them carefully and write the technical terms used for pollen transfer methods ‘1’, ‘2’ and ‘3’.
How do the following plants achieve pollination successfully?

Water lily
Vallisneria
Write advantages of pollen transfer in method ‘3’. \begin{center} OR \end{center} (B)

Given below is the diagram of human ovum surrounded by a few sperms. Observe the diagram and answer the questions that follow:
human ovum surrounded by a few sperms


Compare the fate of sperms ‘P’, ‘Q’ and ‘R’ shown in the diagram.
Write the role of Zona pellucida in this process.
Analyse the changes occurring in the ovum after the entry of sperm.
How acrosome and middle piece of a human sperm are able to play an important role in human fertilization?
35
PYQ 2025
medium
biology ID: cbse-cla
Study the graphs given below for Case 1 and Case 2 showing different levels of certain hormones and answer the question that follows:
different levels of certain hormones
(a) Which hormone is responsible for the peak observed in Case 1 and Case 2? Write one function of that hormone.
(b) Write changes that take place in the ovary and uterus during follicular phase.
Student to attempt either sub-part (c) or (d):
(c) Name the hormone Q of Case 2. Write one function of hormone Q.
\begin{center} OR
\end{center} (d) Which structure in the ovary will remain functional in Case 2? How is it formed?
36
PYQ 2025
medium
biology ID: cbse-cla
Shyam and Radha are expecting their first child with Radha being in her second month of pregnancy with no complications. Shyam’s family has a history of cystic fibrosis while Radha’s family has a history of Down’s syndrome, leading to a concern that the baby may have one of these conditions.
(a) Suggest and explain a way of testing if their baby is at risk for any genetic disorders.
(b) In case of presence of one or both of the abnormalities and posing a risk to the mother’s health, mention one possible option for them to consider. Is that option safe for Radha at the current gestational age? Justify.
(c) Under what conditions is the process mentioned in (b) illegal?
37
PYQ 2025
medium
biology ID: cbse-cla
Assertion (A): Saheli is the World’s first non-steroidal oral contraceptive pill.
Reason (R): It has been developed by National Institute of Immunology, New Delhi.
1
Both (A) and (R) are true and (R) is the correct explanation of (A).
2
Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3
(A) is true, but (R) is false.
4
(A) is false, but (R) is true.
38
PYQ 2025
medium
biology ID: cbse-cla
Given below are a few statements with reference to the accessory ducts of the human male reproductive system:
  • [(i)] The seminiferous tubules of the testes open into rete testis then into the vas deferens.
  • [(ii)] The vasa efferentia leave the testes and open into the epididymis.
  • [(iii)] The epididymis leads to vas deferens that ascends into the abdomen.
  • [(iv)] The vas deferens receives a duct from the prostrate gland and opens into the urethra as ejaculatory duct.
  • [(v)] The urethra originates from the urinary bladder and extends through the penis to its external opening, urethral meatus.
Choose the option with all true statements from the given options:
1
(i), (ii), (iv)
2
(ii), (iii), (v)
3
(ii), (iv), (v)
4
(i), (iii), (iv)
39
PYQ 2025
medium
biology ID: cbse-cla
Menstrual cycle in human females consists of various events. Select the option that indicates the correct sequence of these events of menstrual cycle.
1
Menstrual phase, Follicular phase, Luteal phase, Ovulatory phase
2
Menstrual phase, Follicular phase, Ovulatory phase, Luteal phase
3
Menstrual phase, Follicular phase, Ovulatory phase, Luteal phase
4
Follicular phase, Luteal phase, Menstrual phase, Ovulatory phase
40
PYQ 2025
medium
biology ID: cbse-cla
Explain the neuroendocrine mechanism involved in the process of parturition in a human female leading to the expulsion of the baby out of the uterus through the birth canal.
41
PYQ 2025
medium
biology ID: cbse-cla
Explain what is meant by the term amniocentesis. How is this technique misused in India?
42
PYQ 2025
hard
biology ID: cbse-cla
Assertion (A): Cu-T, Cu-7 and LNG-20 are the most widely used copper-releasing IUDs.
Reason (R): Cu-ions in IUDs effectively suppress sperm motility and the fertilising capacity of sperms.
1
Both (A) and (R) are true and (R) is the correct explanation of (A).
2
Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3
(A) is true, but (R) is false.
4

(A) is false, but (R) is true.

43
PYQ 2025
medium
biology ID: cbse-cla
Given below are few statements with respect to the process of oogenesis in a human ovary:
(i) Each granulosa cell gets surrounded by a primary oocyte to form the primary follicle.
(ii) A couple of million of oogonia are formed within each fetal ovary during the embryonic development.
(iii) Tertiary follicle is characterised by antrum and theca layers.
(iv) Secondary follicles form a zona pellucida layer around it.
(v) Mature graafian follicle ruptures to release the secondary oocyte from the ovary.
Choose the option with all true statements from the given options:
1
(i), (iii), (iv)
2
(ii), (iii), (iv), (v)
3
(ii), (iv), (v)
4
(i), (iii), (v)
44
PYQ 2025
medium
biology ID: cbse-cla

(a) (i) Explain how does double fertilisation take place in a flowering plant.
(ii) Write the fate of the products of double fertilization in these plants.

OR

(b) (i) Explain the structure of testicular lobules in the human male reproductive system. Name the two types of cells present in the seminiferous tubules and state their role.
(ii) Describe the role of hypothalamic hormone GnRH in spermatogenesis.

45
PYQ 2025
medium
biology ID: cbse-cla
Explain the process of formation of placenta in a human female after the implantation of the blastocyst in the endometrium of the uterus.
46
PYQ 2025
medium
biology ID: cbse-cla
Assertion (A): ‘Saheli’, an oral contraceptive inhibits ovulation and increases phagocytosis of sperms.
Reason (R): It is a non-steroidal preparation.
1
Both (A) and (R) are true and (R) is the correct explanation of (A).
2
Both (A) and (R) are true, but (R) is not the correct explanation of (A).
3
(A) is true, but (R) is false.
4
(A) is false, but (R) is true.
47
PYQ 2025
medium
biology ID: cbse-cla
Match the following items of Column-I with that of Column-II:
Column-IColumn-II
(a) Trophoblast(iv) Outer layer of blastocyst
(b) Implantation(i) Embedding of blastocyst in the endometrium
(c) Inner cell mass(ii) Group of cells that would differentiate as embryo
(d) Morula(iii) Embryo with 8–16 blastomeres
Choose the option that matches Column-I with Column-II correctly:
1
A
2
B
3
C
4
D
48
PYQ 2025
medium
biology ID: cbse-cla

How is the interaction between and its specific bee pollinator one of the best examples of co-evolution? Explain.

49
PYQ 2025
medium
biology ID: cbse-cla
Given below are a few statements with reference to the human sperm.
1. Sperm head contains a large nucleus and a lot of cytoplasm.
2. Mitochondria in the middle piece of a sperm provides ATP for the sperm motility.
3. Posterior part of the sperm head is covered by acrosome.
4. Spermatids undergo maturation into spermatozoa by the process of spermiogenesis.
5. Acrosomal secretions help in the entry of the sperm into the ovum at the time of fertilization.
Choose the option with all true statements from the given options :
1
(i), (ii) and (iv)
2
(ii), (iii) and (v)
3
(ii), (iv) and (v)
4
(i), (iii) and (iv)
50
PYQ 2025
medium
biology ID: cbse-cla
Write the location and function of fimbriae in human female.
51
PYQ 2025
medium
biology ID: cbse-cla
Explain the beneficial role of the following, produced as a result of the processes of biotechnology, to mankind:
Cow named Rosie
52
PYQ 2025
medium
biology ID: cbse-cla
Given below are few statements with reference to the human male reproductive system:
1. Paired seminal vesicles, prostate gland and bulbourethral gland constitute the male accessory glands.
2. Secretions of the male accessory glands constitute the seminal plasma.
3. Secretions of the bulbourethral glands help in the lubrication of the penis.
4. Enlarged end of the the penis is known as foreskin.
5. Seminal plasma is rich in fructose, calcium and certain enzymes.
Choose the option with all true statements from the given options:
1
( \text{(i), (ii) and (iv)} )
2
( \text{(ii), (iii) and (v)} )
3
( \text{(ii), (iv) and (v)} )
4
( \text{(i), (iii) and (v)} ) \
53
PYQ 2026
medium
biology ID: cbse-cla
Trace the events from fertilization till implantation of blastocyst in human female. Also mention the site where fertilization takes place.
54
PYQ 2026
medium
biology ID: cbse-cla
Which connective tissue connects ovary to pelvic wall and uterus?
1
Tendons
2
Ligaments
3
Cartilage
4
Bone
55
PYQ 2026
medium
biology ID: cbse-cla
Select the option that shows correct statements :
(i) Corpus luteum secretes progesterone.
(ii) Only FSH attains a peak level in middle of cycle.
(iii) LH surge induces rupture of graafian follicle.
(iv) Luteal phase of menstrual cycle is also called proliferative phase.

1
Only (ii) is correct.
2
(i) and (iii) are correct.
3
Only (iv) is correct.
4
(ii) and (iv) are correct.
56
PYQ 2026
medium
biology ID: cbse-cla
Identify the stage of follicle where primary oocyte undergoes first meiotic division. Also mention the products of this division.
57
PYQ 2026
medium
biology ID: cbse-cla
Briefly explain the events of fertilisation and implantation in an adult human female.